Department of Neurosciences, CUCS, Universidad de Guadalajara, 44630 Guadalajara, JAL, Mexico.
Stem Cells Int. 2012;2012:470949. doi: 10.1155/2012/470949. Epub 2012 Sep 10.
The advent and growth of technological advances have led to new routes of knowledge. Thereby, we currently face new challenges. We have just started to get a glimpse of the structural and functional role of neural stem cells in differentiation and migration processes, the origin of synaptic networks, and subsequent readjustments in specific circuits. A whole range of treatment possibilities originates from this knowledge that potentially can be used for different neurological diseases in humans. Although this is an encouraging scenario, it implies that the human brain is the object of such study, as well as its potential manipulation and transplantation. It is, therefore, pertinent that ethical principles should be followed in such research to have proper balance between what can be done and what should be done, according to every specific context. Hence, it is wise to consider ethical implications in every research project, along with potential clinical applications, under the principle of causing no harm, following risk and benefit rules in decision making and with respect of the human condition as a priority.
科技进步的出现和发展带来了新的知识途径。因此,我们目前面临着新的挑战。我们才刚刚开始了解神经干细胞在分化和迁移过程中的结构和功能作用、突触网络的起源以及特定回路的后续调整。从这些知识中产生了一系列治疗可能性,这些可能性有可能用于人类的不同神经疾病。尽管这是一个令人鼓舞的情况,但它意味着人类大脑是此类研究的对象,以及对其进行潜在的操作和移植。因此,在进行此类研究时,应该遵循伦理原则,根据每个具体情况,在可以做什么和应该做什么之间取得适当的平衡。因此,明智的做法是在每个研究项目中,考虑潜在的临床应用,同时考虑到不造成伤害的原则,遵循风险和收益规则进行决策,并优先考虑人类的状况。