Farina Roberto, Bressan Eriberto, Taut Andrei, Cucchi Alessandro, Trombelli Leonardo
Research Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Ferrara, Italy.
Clin Oral Implants Res. 2013 Dec;24(12):1360-8. doi: 10.1111/clr.12033. Epub 2012 Sep 24.
To determine whether and to what extent the additional application of plasma rich in growth factors (PRGF) to an extraction socket may influence the early bone deposition, as assessed by micro-computed tomography (micro-CT) scan as well as histomorphometric markers.
Twenty-eight patients (age range: 34-74 years) contributing 36 extraction sockets were included in the study. Sockets were either treated with PRGF (PRGF group; 18 sites in 11 patients) or left to spontaneous healing (control group; 18 sites in 17 patients). Radiographic and histomorphometric analysis was performed on bone cores trephined from each healing socket after 4-6 (T1) or 7-10 (T2) weeks of healing.
Patients treated with PRGF application showed (i) similar bone volume and tissue mineral content, (ii) a trend, although not statistically significant, toward a greater number of CD68+ cells (at T1 and T2) and vVW+ cells (at T1), and (iii) a similar OCN staining score throughout the study, when compared with control group.
Plasma rich in growth factors-treated group did not show any enhancement in early (4 and 8 weeks) bone deposition compared with control group.
通过显微计算机断层扫描（micro-CT）以及组织形态计量学指标评估，确定在拔牙窝额外应用富含生长因子的血浆（PRGF）是否以及在何种程度上会影响早期骨沉积。
本研究纳入了28例患者（年龄范围：34 - 74岁），共36个拔牙窝。拔牙窝要么接受PRGF治疗（PRGF组；11例患者的18个位点），要么任其自然愈合（对照组；17例患者的18个位点）。在愈合4 - 6周（T1）或7 - 10周（T2）后，对从每个愈合拔牙窝钻取的骨芯进行影像学和组织形态计量学分析。
与对照组相比，接受PRGF治疗的患者表现为：（i）骨体积和组织矿物质含量相似；（ii）CD68 +细胞数量（在T1和T2时）和vVW +细胞数量（在T1时）有增加趋势，尽管无统计学意义；（iii）在整个研究过程中骨钙素（OCN）染色评分相似。
与对照组相比，富含生长因子的血浆治疗组在早期（4周和8周）骨沉积方面未显示出任何增强。
