School of Geography, Earth & Env. Sciences, University of Birmingham, B15 2TT, UK.
Sci Total Environ. 2012 Nov 1;438:225-32. doi: 10.1016/j.scitotenv.2012.08.066. Epub 2012 Sep 19.
Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation.
纳米颗粒（NPs）的溶解是一种改变其丰度的重要性质，通常是确定纳米颗粒安全性的关键步骤。纳米颗粒在暴露介质中的溶解状态（即它们是否仍保持颗粒形式或溶解以及溶解程度），强烈影响摄取途径、毒性机制以及纳米颗粒将具有最大潜在影响的环境隔室。对现有纳米颗粒溶解数据的综述表明，取决于纳米颗粒和暴露介质，存在一系列潜在结果。例如，在大小和组成方面名义上相同的两个纳米颗粒，由于表面修饰不同，可能具有完全不同的溶解行为。因此，必须结合纳米颗粒的溶解进行毒理学研究，以确定纳米颗粒的真实生物学效应，从而有助于对其进行监管。
