Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Phys Rev Lett. 2012 Sep 7;109(10):108103. doi: 10.1103/PhysRevLett.109.108103. Epub 2012 Sep 5.
The chemotaxis of eukaryotic cells depends both on the average concentration of the chemoattractant and on the steepness of its gradient. For the social amoeba Dictyostelium discoideum, we test quantitatively the prediction by Ueda and Shibata [Biophys. J. 93, 11 (2007)] that the efficacy of chemotaxis depends on a single control parameter only, namely, the signal-to-noise ratio (SNR), determined by the stochastic fluctuations of (i) the binding of the chemoattractant molecule to the transmembrane receptor and (ii) the intracellular activation of the effector of the signaling cascade. For SNR < or approximately equal to 1, the theory captures the experimental findings well, while for larger SNR noise sources further downstream in the signaling pathway need to be taken into account.
真核细胞的趋化性既依赖于趋化剂的平均浓度，也依赖于其浓度梯度的陡度。对于社会性阿米巴虫 Dictyostelium discoideum，我们定量测试了 Ueda 和 Shibata 的预测[生物物理学杂志 93, 11 (2007)]，即趋化作用的效果仅取决于一个单一的控制参数，即信号噪声比（SNR），由（i）趋化剂分子与跨膜受体的结合和（ii）信号级联的效应物的细胞内激活的随机波动决定。对于 SNR < 或约等于 1，该理论很好地捕捉了实验结果，而对于更大的 SNR，需要考虑信号通路下游的噪声源。
