Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20007, USA.
J Clin Invest. 2012 Oct;122(10):3471-3. doi: 10.1172/JCI65380. Epub 2012 Sep 24.
In addition to its role in refraction, the cornea forms a barrier between the eye and environmental and infectious insults. Corneal infections are surprisingly rare, suggesting that multiple aspects of the immune system are at play in mediating protection. In this issue of the JCI, Tam et al. describe the unexpected role of a structural protein, cytokeratin 6A, in this process.
除了在折射中的作用外，角膜在眼睛和环境及感染性侵袭之间形成了一道屏障。令人惊讶的是，角膜感染非常少见，这表明免疫系统的多个方面都在发挥作用以介导保护。在本期 JCI 中，Tam 等人描述了结构蛋白角蛋白 6A 在这个过程中的意外作用。
