Department of Clinical Pharmacology, University Hospital Dubrava, Av. Gojka Suska 6, 10000, Zagreb, Croatia.
Int J Clin Pharm. 2013 Feb;35(1):37-44. doi: 10.1007/s11096-012-9700-9. Epub 2012 Sep 25.
To evaluate the impact of pharmacotherapeutic counseling on the rates and causes of 30-day post-discharge hospital readmissions and emergency department visits.
The study was conducted at the Medical Clinic of University Hospital Dubrava, Zagreb, Croatia.
The study included elderly patients prescribed with two or more medications for the treatment of chronic diseases. The patients randomized into the intervention group received pre-discharge counseling by the clinical pharmacologist about each prescribed medication. The control group received no counseling.
The rates and causes of 30-day postdischarge hospital readmissions and emergency department visits. Medication compliance was also evaluated, using the pill count method.
A total of 160 patients were randomly selected for the study. No significant difference was found in the readmission and emergency department visit rates between the intervention and control groups (p = 0.224). There were 34.9 % more compliant patients in the intervention group. Significantly more non-compliant patients in the control group were readmitted or visited emergency department because of the disease progression (p = 0.031). In the intervention group, significantly more patients were readmitted or visited emergency department because of an adverse drug reaction (p = 0.022).
Pharmacotherapeutic counseling can reduce readmission and emergency department visit rates for disease progression. Improved patient knowledge about adverse drug reactions could be the reason for increased rates of readmissions and emergency department visits due to adverse drug reactions in the intervention group.
评估药物治疗咨询对 30 天出院后再入院和急诊就诊率及原因的影响。
该研究在克罗地亚萨格勒布杜布拉瓦大学医院的医疗诊所进行。
该研究纳入了服用两种或多种药物治疗慢性病的老年患者。将随机分配到干预组的患者在出院前由临床药师对每种开处的药物进行咨询。对照组患者则未接受咨询。
30 天出院后再入院和急诊就诊率及原因。还使用药片计数法评估了药物依从性。
共随机选择了 160 名患者进行研究。干预组和对照组的再入院和急诊就诊率无显著差异(p = 0.224)。干预组中依从性更高的患者比例高 34.9%。对照组中因疾病进展而不依从的患者再入院或急诊就诊的比例更高(p = 0.031)。在干预组中,因药物不良反应而再次入院或急诊就诊的患者比例显著更高(p = 0.022)。
药物治疗咨询可降低因疾病进展而再次入院和急诊就诊的几率。患者对药物不良反应的了解得到改善,可能是干预组因药物不良反应而再次入院和急诊就诊的比例增加的原因。