School of Women's and Children's Heath, University of New South Wales, Kensington, NSW, Australia.
Acta Paediatr. 2013 Jan;102(1):e17-23. doi: 10.1111/apa.12039. Epub 2012 Nov 1.
To compare causes and rates of mortality among infants admitted to 10 Australian neonatal intensive care units (NICUs) between 1995 and 2006.
De-identified perinatal data from the Neonatal Intensive Care Units' (NICUS) Data Collection for 24 131 infants were examined for causes and rates of death. The study period was divided into two epochs: I (1995-2000, n = 11 185 infants) and II (2001-2006, n = 12 946 infants).
A total of 2224 (9.2%) infants died in hospital. Mortality decreased from 10.3% (1152/11 185) in epoch I to 8.3% (1072/12 946) in epoch II (p < 0.001) due to improved survival in term infants. Extreme prematurity also decreased as a primary cause of death (118 (10.2%) vs 76 (7.1%), p = 0.008). No infant >42-week gestation was admitted in epoch II. Congenital abnormalities were the most common cause of death (>20%) in both epochs, mostly in term rather than preterm infants (40.7% vs 13.9%, p < 0.001). Age of death was unchanged between the two epochs (median 4, 1st, 3rd quartiles: 1,16 days).
Mortality rates have continued to decrease but improvement is predominantly due to improved survival of term infants and prevention of postdate deliveries. Congenital abnormalities continue to be the most common cause of death.
比较 1995 年至 2006 年间澳大利亚 10 家新生儿重症监护病房（NICU）收治的婴儿的死亡原因和死亡率。
对新生儿重症监护病房（NICUs）数据采集的 24131 名婴儿的去识别围产期数据进行了检查，以确定死亡原因和死亡率。研究分为两个时期：I 期（1995-2000 年，n=11185 例婴儿）和 II 期（2001-2006 年，n=12946 例婴儿）。
共有 2224 例（9.2%）婴儿在医院死亡。由于足月婴儿存活率的提高，死亡率从 I 期的 10.3%（1152/11185）降至 II 期的 8.3%（1072/12946）（p<0.001）。极早产儿也减少了作为主要死亡原因（118 例[10.2%]与 76 例[7.1%]，p=0.008）。在 II 期没有>42 周胎龄的婴儿入院。先天性异常是两个时期死亡的最常见原因（>20%），主要发生在足月而非早产儿（40.7%与 13.9%，p<0.001）。两个时期的死亡年龄无变化（中位数 4 天，第 1、3 四分位数：1、16 天）。
死亡率继续下降，但改善主要是由于足月婴儿存活率的提高和避免过期分娩。先天性异常仍然是最常见的死亡原因。
