Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ann Allergy Asthma Immunol. 2012 Oct;109(4):249-54. doi: 10.1016/j.anai.2012.07.019. Epub 2012 Aug 15.
Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAHs), can induce asthma. However, the effects of early repeated PAH exposure over time on different asthma phenotypes have not been examined.
To assess associations between repeated PAH exposure, measured from prenatal personal and residential indoor monitors in children's homes, and asthma in an inner-city cohort.
Prenatal exposure was assessed by personal air monitoring during 48 hours and exposure at 5 to 6 years of age by 2-week residential monitoring in the Columbia Center for Children's Environmental Health cohort. PAH was dichotomized into pyrene (representative semivolatile PAH) and the sum of 8 nonvolatile PAHs. High exposure to each was defined as measures above the median at both repeated time points. Asthma and wheeze were determined by validated questionnaires at ages 5 to 6 years. Children with specific IgE levels greater than 0.35 IU/mL to any of 5 indoor allergens were considered seroatopic.
Among all 354 children, repeated high exposure to pyrene was associated with asthma (odds ratio [OR], 1.90; 95% confidence interval [CI], 1.13-3.20). Among 242 nonatopic children, but not those sensitized to indoor allergens (n = 87) or with elevated total IgE levels (n = 171), high pyrene levels were associated positively with asthma (OR, 2.89; 95% CI, 1.77-5.69), asthma medication use (OR, 2.28; 95% CI, 1.13-4.59), and emergency department visits for asthma (OR, 2.43; 95% CI, 1.20-4.91). Associations between the levels of the 8 nonvolatile PAHs and asthma were not observed, even when stratifying by seroatopy.
Nonatopic children may be more susceptible to the respiratory consequences of early pyrene exposures.
接触交通相关的空气污染物，包括多环芳烃（PAHs），可能会引发哮喘。然而，早期反复暴露于 PAH 对不同哮喘表型的影响尚未被研究。
评估儿童家中的个人和住宅室内监测器测量的重复 PAH 暴露与城市内队列中哮喘之间的关联。
通过在哥伦比亚儿童环境健康中心队列中，在 48 小时内进行个人空气监测和在 5 至 6 岁时进行为期 2 周的住宅监测来评估产前暴露。PAH 分为芘（代表性半挥发性 PAH）和 8 种非挥发性 PAH 的总和。在两个重复时间点上，每种物质的测量值均高于中位数，被定义为高暴露。在 5 至 6 岁时，通过经过验证的问卷调查来确定哮喘和喘息情况。对于任何 5 种室内过敏原的特异性 IgE 水平大于 0.35 IU/mL 的儿童被认为是血清阳性。
在所有 354 名儿童中，重复高暴露于芘与哮喘有关（比值比 [OR]，1.90；95%置信区间 [CI]，1.13-3.20）。在 242 名非特应性儿童中，但在室内过敏原致敏的儿童（n=87）或总 IgE 水平升高的儿童（n=171）中，高芘水平与哮喘呈正相关（OR，2.89；95% CI，1.77-5.69），哮喘药物使用（OR，2.28；95% CI，1.13-4.59）和因哮喘急诊就诊（OR，2.43；95% CI，1.20-4.91）。即使按血清阳性进行分层，也未观察到 8 种非挥发性 PAHs 水平与哮喘之间的关联。
非特应性儿童可能更容易受到早期芘暴露的呼吸道影响。
