Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, WA, USA.
Ann Allergy Asthma Immunol. 2012 Oct;109(4):260-265.e2. doi: 10.1016/j.anai.2012.07.024. Epub 2012 Aug 15.
Despite effective medications, asthma remains a significant burden to the US health care system.
To determine whether partly and uncontrolled asthma in respondents to the Asthma Insights and Management (AIM) survey was associated with adverse outcomes (such as visits to health care professionals and medication use) compared with well-controlled asthma.
The AIM survey, conducted in 2009, included 2,500 patients with asthma who were 12 years or older. We classified patients into levels of control and compared use of health care services and limitations of activities in patients whose asthma was well controlled vs those with partly and uncontrolled asthma.
Patients who reported lower income and educational status and lacked health insurance were less likely to have had well-controlled asthma. Respondents with uncontrolled asthma were more likely to report ever use of oral steroids (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.9-3.2) and over-the-counter medicine (OR, 2.7; 95% CI, 2.0-3.7) compared with patients whose asthma was well controlled. Respondents with partly and uncontrolled asthma were also significantly more likely to report ever visiting physicians, specialists, or the emergency department or being hospitalized for asthma compared with those whose asthma was well controlled (ORs ranging from 2.1 to 5.6). Finally, respondents whose asthma was uncontrolled had increased odds (ORs ranging from 14 to 34) of reporting that asthma limited their activities compared with respondents whose asthma was well controlled.
Patients with partly and uncontrolled asthma defined by international guidelines reported use of significantly more health care resources and greater limitations of their daily activities compared with patients whose asthma was well controlled.
尽管有有效的药物治疗,但哮喘仍是美国医疗体系的重大负担。
通过哮喘洞察和管理(AIM)调查,确定与控制良好的哮喘相比,部分控制和未控制的哮喘是否与不良结果(如就诊和药物使用)相关。
2009 年进行的 AIM 调查纳入了 2500 名年龄在 12 岁及以上的哮喘患者。我们将患者分为控制水平,并比较控制良好的哮喘患者与部分控制和未控制的哮喘患者使用医疗服务和活动受限的情况。
报告收入和教育程度较低且缺乏医疗保险的患者更不可能有控制良好的哮喘。未控制哮喘的患者更有可能报告曾使用口服类固醇(比值比[OR],2.5;95%置信区间[CI],1.9-3.2)和非处方药物(OR,2.7;95% CI,2.0-3.7),而控制良好的哮喘患者则较少。与控制良好的哮喘患者相比,部分控制和未控制哮喘的患者也更有可能报告曾就诊于医生、专科医生或急诊室或因哮喘住院(OR 范围为 2.1-5.6)。最后,与控制良好的哮喘患者相比,未控制哮喘的患者报告哮喘活动受限的几率显著增加(OR 范围为 14-34)。
根据国际指南定义的部分控制和未控制哮喘患者报告使用了更多的医疗资源,且日常活动受限的程度也更大,与控制良好的哮喘患者相比。