Tang Christopher G, Schmidtknecht Thomas M, Tang Grace Y, Schloegel Luke J, Rasgon Barry
Head and Neck Surgery Department, Oakland Medical Center, CA, USA.
Perm J. 2012 Summer;16(3):60-2. doi: 10.7812/TPP/12.963.
A 29-year-old woman presented from another hospital with a 10-month history of an enlarging left-sided facial mass. Computed tomographic scan revealed a mass in the superficial lobe of the left parotid gland with left-sided cervical lymphadenopathy. The patient received a total left parotidectomy and a selective neck dissection. Histopathologic slides revealed lymphoepithelial carcinoma (LEC) that stained positive for cytokeratin, as well as Epstein-Barr virus (EBV). An LEC of the parotid is a rare salivary gland tumor accounting for less than 1% of all salivary gland tumors. As reaffirmed in our case, LEC is more common in women, occurs primarily in the parotid gland, and has an ethnic predilection. Histologic analysis reveals an infiltrative, poorly differentiated tumor nestled in a lymphoid stroma, with near 100% positivity for EBV in endemic areas. Complete resection of this poorly differentiated carcinoma followed by postoperative radiation is essential for local control.
一名29岁女性从另一家医院转诊而来，左侧面部肿物增大已有10个月。计算机断层扫描显示左腮腺浅叶有肿物，并伴有左侧颈部淋巴结病。患者接受了左侧腮腺全切术和选择性颈部淋巴结清扫术。组织病理学切片显示为淋巴上皮癌（LEC），细胞角蛋白及爱泼斯坦-巴尔病毒（EBV）染色呈阳性。腮腺LEC是一种罕见的涎腺肿瘤，占所有涎腺肿瘤的比例不到1%。正如我们病例所再次证实的，LEC在女性中更为常见，主要发生于腮腺，且有种族倾向。组织学分析显示，肿瘤呈浸润性、低分化，位于淋巴样间质中，在流行地区EBV阳性率接近100%。彻底切除这种低分化癌并术后放疗对于局部控制至关重要。
