McLean Hospital, Belmont, MA 02478, USA.
J Pers Disord. 2012 Oct;26(5):804-14. doi: 10.1521/pedi.2012.26.5.804.
The objectives of this study were to assess the rates of comorbid anxiety disorders other than PTSD in patients with borderline personality disorder (BPD) and Axis II comparison subjects over ten years of prospective follow-up and to determine time-to-remission, recurrence, and new onset of these disorders. The SCID I was administered to 290 borderline patients and 72 Axis II comparison subjects at baseline and at five contiguous 2-year follow-up waves. The rates of anxiety disorders for those in both groups declined significantly over time, although they remained significantly higher among borderline patients. By 10-year follow-up, the rates of remission for borderline patients who met criteria for these disorders at baseline were high, while the rates of recurrences and new onsets were moderate. These results suggest that anxiety disorders are very common over time among borderline patients. They also suggest that these disorders have an intermittent course among those with BPD.
本研究的目的是评估在十年前瞻性随访中，边缘型人格障碍（BPD）患者和轴 II 对照受试者中除创伤后应激障碍（PTSD）以外的共病焦虑障碍的发生率，并确定这些障碍的缓解时间、复发和新发病例。在基线和连续的 5 个 2 年随访中，对 290 名边缘型患者和 72 名轴 II 对照受试者进行了 SCID I 诊断。尽管边缘型患者的焦虑障碍发生率仍然显著高于对照组，但两组的焦虑障碍发生率随着时间的推移均显著下降。在 10 年随访时，基线时符合这些障碍标准的边缘型患者的缓解率较高，而复发和新发病例率则处于中等水平。这些结果表明，焦虑障碍在边缘型患者中随着时间的推移非常常见。它们还表明，这些障碍在 BPD 患者中具有间歇性病程。
