仿生全合成（±）-garcibracteatone。

Biomimetic total synthesis of (±)-garcibracteatone.

机构信息

School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5005, Australia.

出版信息

Org Lett. 2012 Oct 5;14(19):5162-4. doi: 10.1021/ol302524q. Epub 2012 Sep 26.

Abstract

The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.

摘要

多环聚多烯基酰基间苯三酚天然产物 garcibracteatone 已通过基于生物合成推测的策略从间苯三酚合成，共四步。关键的仿生转化是 7-endo-trig 和 5-exo-trig 自由基环化的级联反应，随后是终止的芳香取代反应。