Horstkotte Elke, Odoerfer Kathrin I
leon-nanodrugs GmbH, Kopernikusstrasse 9, 81679 Munich, Germany.
Recent Pat Food Nutr Agric. 2012 Dec;4(3):220-44. doi: 10.2174/2212798411204030220.
Pharmaceutical formulations that contain nanosized drugs are perceived as "Nanopharmaceuticals" and offer significant benefit for the patient compared to the conventional formulated drugs. There are several advantages of nanoparticular drug formulations such as enhanced solubility and dissolution rate, enhanced oral bioavailability, improved dose proportionality, reduced food effects, suitability for administration by all routes and possibility of sterile filtration due to decreased particle size range. Several nanopharmaceuticals are successfully marketed. Different patented techniques are commercialized to prepare nanopharmaceuticals such as milling, homogenization and precipitation. The focus of the underlying review is to give an overview of those technologies for nanosizing active pharmaceutical ingredients and recently published patents in the field of nanosized pharmaceutics.
含有纳米级药物的药物制剂被视为“纳米药物”，与传统制剂药物相比，对患者具有显著益处。纳米颗粒药物制剂有诸多优点，如溶解度和溶解速率提高、口服生物利用度增强、剂量比例性改善、食物影响减小、适合所有给药途径以及因粒径范围减小而具备无菌过滤的可能性。几种纳米药物已成功上市。不同的专利技术已商业化用于制备纳米药物，如研磨、均质化和沉淀。本综述的重点是概述那些用于将活性药物成分纳米化的技术以及纳米制药领域最近公布的专利。
