Department of Public Health, Section of Environmental and Occupational Medicine, Aarhus University, Aarhus, Denmark.
Occup Environ Med. 2013 Jan;70(1):22-8. doi: 10.1136/oemed-2011-100648. Epub 2012 Sep 26.
Acute lung function (LF) changes might predict an accelerated decline in LF. In this study, we investigated the association between cross-shift and longitudinal changes in forced expiratory volume in 1 s (FEV(1)) among woodworkers in a 6-year follow-up study.
817 woodworkers and 136 controls participated with cross-shift changes of FEV(1) at baseline and FEV(1) and forced vital capacity at follow-up. Height and weight were measured and questionnaire information on respiratory symptoms, employment and smoking habits was collected. Wood dust exposure was assessed from 3572 personal dust measurements at baseline and follow-up. Cumulative wood dust exposure was assessed by a study-specific job exposure matrix and exposure time.
The median (range) of inhalable dust at baseline and cumulative wood dust exposure was 1.0 (0.2-9.8) mg/m(3) and 3.8 (0-7.1) mg year/m(3), respectively. Mean (SD) for %ΔFEV(1)/workday and ΔFEV(1)/year was 0.2 (6.0)%, and -29.1 (41.8) ml. Linear regression models adjusting for smoking, age, height and weight change showed no association between cross-shift and annual change in FEV(1) among woodworkers or controls. Including different exposure estimates, atopy or cross-shift change dichotomised or as quartiles did not change the results.
This study among workers exposed to low levels of wood dust does not support an association between acute LF changes and accelerated LF decline.
急性肺功能 (LF) 变化可能预示 LF 加速下降。本研究通过 6 年随访研究，调查了木工在跨班次和纵向用力呼气量 1 秒 (FEV1) 变化之间的关系。
817 名木工和 136 名对照者参加了研究，基线时检测了跨班次 FEV1 的变化，随访时检测了 FEV1 和用力肺活量。测量了身高和体重，并收集了关于呼吸道症状、就业和吸烟习惯的问卷调查信息。基线和随访时，使用 3572 份个人粉尘测量值评估了木粉尘暴露。使用特定于研究的工作暴露矩阵和暴露时间评估了累积木粉尘暴露。
基线和累积木尘暴露的中位值（范围）分别为 1.0（0.2-9.8）mg/m3 和 3.8（0-7.1）mg 年/m3。%ΔFEV1/工作日和 ΔFEV1/年的平均值（标准差）分别为 0.2（6.0）%和-29.1（41.8）ml。线性回归模型调整了吸烟、年龄、身高和体重变化，结果显示木工和对照组之间跨班次和年度 FEV1 变化之间没有关联。包括不同的暴露估计值、特应性或跨班次变化二分法或四分位数，均未改变结果。
在暴露于低水平木尘的工人中进行的这项研究不支持急性 LF 变化与 LF 加速下降之间的关联。
