Division of General Internal Medicine, University at Buffalo, Buffalo, NY, USA.
Alcohol Alcohol. 2013 Jan-Feb;48(1):83-7. doi: 10.1093/alcalc/ags109. Epub 2012 Sep 25.
Hair ethyl glucuronide (EtG) is a promising biomarker of moderate-to-heavy alcohol consumption and may have utility in detecting and monitoring alcohol use in clinical populations where alcohol use is of particular importance. This study evaluated the relationship between hair EtG and drinking in patients with liver disease.
The subjects (n = 200) were patients with liver disease who presented for care at a university medical center. Alcohol use during the 3 months preceding participation in the study was assessed, and a sample of hair was obtained for EtG testing. Classification of drinking status (any drinking or averaging at least 28 g per day) by hair EtG was evaluated, as well as the effects of liver disease severity and demographic and hair care factors.
The area under the receiver operating characteristic curve for detecting an average of 28 g or more per day during the prior 90 days was 0.93. The corresponding sensitivity and specificity of hair EtG ≥8 pg/mg for averaging at least 28 g of ethanol per day were 92 and 87%, respectively. Cirrhosis and gender may have a modest influence on the relationship between drinking and hair EtG.
Hair EtG was highly accurate in differentiating subjects with liver disease averaging at least 28 g of ethanol per day from abstainers and lighter drinkers.
头发中的乙基葡萄糖醛酸（EtG）是一种有前途的中等至大量饮酒生物标志物，可能在检测和监测具有特殊意义的临床人群中的酒精使用方面具有实用性。本研究评估了头发 EtG 与肝病患者饮酒之间的关系。
研究对象（n=200）为在大学医疗中心就诊的肝病患者。评估了他们在参与研究前 3 个月的饮酒情况，并采集头发样本进行 EtG 检测。评估了头发 EtG 对饮酒状态（任何饮酒或平均每天至少 28 克）的分类，以及肝病严重程度和人口统计学及头发护理因素的影响。
在过去 90 天内平均每天至少 28 克的受试者中，检测到平均每天至少 28 克的受试者的受试者工作特征曲线下面积为 0.93。头发 EtG≥8pg/mg 用于平均每天至少 28 克乙醇的敏感性和特异性分别为 92%和 87%。肝硬化和性别可能对饮酒和头发 EtG 之间的关系有一定影响。
头发 EtG 高度准确地区分了平均每天至少 28 克乙醇的肝病患者与戒酒者和轻度饮酒者。
