Hernández-Ledesma B, Hsieh C C, de Lumen B O
Institute of Food Science Research (CIAL, CSIC-UAM). Nicolás Cabrera, 9. Campus de la Universidad Autónoma de Madrid. 28049 Madrid, Spain.
Protein Pept Lett. 2013 Apr;20(4):424-32.
Cancer has become one the most common causes of death in developed countries and has been defined as the medical challenge of our times. Accumulating evidence support the notion that prevention can be a major component of cancer control. Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural and/or synthetic substances to block, reverse, or retard the process of carcinogenesis. Plant-based foods, containing significant amounts of bioactive phytochemicals, may provide desiderable health benefits beyond basic nutrition to reduce the process of cancer. In the last few years, proteins and peptides have become one group of nutraceuticals that show potential results in preventing the different stages of cancer including initiation, promotion, and progression. Lunasin is a 43- amino acid peptide identified in soybean and other plants whose anti-carcinogenic activity has been demonstrated both in in vitro and in vivo assays. Moreover, this peptide has been found to exert anti-inflammatory and antioxidant properties that could contribute to its chemopreventive effects. Lunasin's bioactivity and its molecular mechanism(s) of actions are summarized in this review.
癌症已成为发达国家最常见的死因之一，并被定义为我们这个时代的医学挑战。越来越多的证据支持预防可以成为癌症控制的一个主要组成部分这一观点。化学预防是一种相对较新且有前景的预防癌症的策略，它被定义为使用天然和/或合成物质来阻断、逆转或延缓致癌过程。含有大量生物活性植物化学物质的植物性食物，除了提供基本营养外，可能还具有理想的健康益处，以减少癌症发生过程。在过去几年中，蛋白质和肽已成为一类营养保健品，在预防癌症的不同阶段（包括起始、促进和进展）方面显示出潜在效果。萝卜硫素是一种在大豆和其他植物中发现的由43个氨基酸组成的肽，其抗癌活性已在体外和体内试验中得到证实。此外，已发现这种肽具有抗炎和抗氧化特性，这可能有助于其化学预防作用。本文综述了萝卜硫素的生物活性及其作用的分子机制。
