Alimentary Health Ltd., Cork, Ireland.
Gut Microbes. 2013 Jan-Feb;4(1):48-53. doi: 10.4161/gmic.22328. Epub 2012 Sep 27.
Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut microbiota may affect the risk of developing obesity and related disorders has led to an explosion of interest in this distinct research field. A corollary of these findings would suggest that modulation of gut microbial populations can have beneficial effects with respect to controlling obesity. In this addendum, we summarize our recent data, showing that therapeutic manipulation of the microbiota using different antimicrobial strategies may be a useful approach for the management of obesity and metabolic conditions. In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases.
肥胖与许多严重的健康后果有关，包括 2 型糖尿病、心血管疾病和多种癌症等，并且已经反复证明与更高的死亡率风险相关。最近的发现表明，肠道微生物组的组成和代谢活性可能会影响肥胖和相关疾病的发病风险，这引发了人们对这一独特研究领域的浓厚兴趣。这些发现的必然结果表明，调节肠道微生物种群可能对控制肥胖具有有益的效果。在本增刊中，我们总结了我们最近的数据，表明使用不同的抗菌策略对微生物组进行治疗性操作可能是管理肥胖和代谢疾病的一种有用方法。此外，我们还将探讨一些可能导致微生物组诱导肥胖和代谢疾病易感性的机制。
