Tyagi Parimala, Dixit U, Tyagi Sanjeev, Jain Ankur
Department of Pedodontics and Preventive Dentistry, People's Dental Academy, Bhopal, Madhya Pradesh, India.
J Clin Pediatr Dent. 2012 Summer;36(4):383-8. doi: 10.17796/jcpd.36.4.t1j3625831144371.
To evaluate and compare the behavioral changes and effect of sedative techniques in pediatric dental patients using Oral Midazolam, Intravenous Midazolam and Oral Diazepam as sedative agents.
Triple blind randomized control trial with 40 patients aged between 2-10 years, exhibiting definitely negative behavior was considered Patients were randomly assigned to one of the four treatment groups. Group I received midazolam 0.5 mg/kg orally, Group II received 0.5 mg/kg diazepam orally, Group III received 0.06 mg/kg midazolam intravenously and Group IV received oral placebo. Behavioral changes (sleep, crying, movement, and overall behavior) and effect of sedative techniques on pediatric patients were assessed.
All the patients in group 3 were significantly better in post administrative behavior viz. sleep, crying and movement. Over all behavior scores for group 3 patients were significantly better than other three groups (p < 0.001). Positive behavior of patients in group 2 and 3 did not show significant difference but positive behavior in group 3 was significantly (p < 0.05) more than group 2. Placebo group showed the highest negative behavior.
Sedative effects of oral midazolam and oral diazepam were comparable, where as intravenous midazolam produced more sedation. Anxiolysis was found to be more in both the midazolam groups than the diazepam group. Most number of positive changes were observed in midazolam groups as compared to diazepam group.
评估并比较使用口服咪达唑仑、静脉注射咪达唑仑和口服地西泮作为镇静剂时，儿科牙科患者的行为变化及镇静技术的效果。
对40名年龄在2至10岁、表现出明显负面行为的患者进行三盲随机对照试验。患者被随机分配到四个治疗组之一。第一组口服0.5毫克/千克咪达唑仑，第二组口服0.5毫克/千克地西泮，第三组静脉注射0.06毫克/千克咪达唑仑，第四组口服安慰剂。评估行为变化（睡眠、哭闹、活动及总体行为）以及镇静技术对儿科患者的效果。
第三组所有患者在给药后的行为，即睡眠、哭闹和活动方面均明显更好。第三组患者的总体行为评分明显优于其他三组（p < 0.001）。第二组和第三组患者的积极行为无显著差异，但第三组的积极行为明显多于第二组（p < 0.05）。安慰剂组表现出最高的负面行为。
口服咪达唑仑和口服地西泮的镇静效果相当，而静脉注射咪达唑仑产生的镇静作用更强。发现咪达唑仑组的抗焦虑作用均比地西泮组更强。与地西泮组相比，咪达唑仑组观察到的积极变化最多。
