Department of Electrical and Electronic Engineering, College of Industrial Technology, Nihon University, 1-2-1, Izumicho, Narashino, Chiba 275-8575 Japan.
Phys Med Biol. 2012 Oct 21;57(20):6615-33. doi: 10.1088/0031-9155/57/20/6615. Epub 2012 Oct 1.
Spread-out Bragg peaks made by ridge filters or wheel range modulators are used in charged particle therapy with passive methods to achieve uniform biological responses in irradiated tumors. Following the biological responses needed to design the ridge filters, which were developed at the National Institute of Radiological Sciences in Japan, new ridge filters were designed using recent developments in heavy-ion reactions and dosimetry. The Monte Carlo code of Geant4 was used to calculate the qualities of carbon ion beams in a water phantom. The results obtained from the simulation were corrected so that they agreed with the measurements of depth dose distributions. The calculations of biological responses to fragments other than carbon ions were assumed to be for helium ions. The measured dose distributions with the designed ridge filters were compared to the calculated distributions. A beam modifying system using this adaptable method was successively applied to carbon ion therapy at Gunma University.
扩展布拉格峰由脊滤波器或轮距调制器产生，在采用被动方法的带电粒子治疗中用于实现照射肿瘤的均匀生物学响应。根据在日本放射线医学综合研究所开发的脊滤波器所需的生物学响应，利用重离子反应和剂量学的最新进展，设计了新的脊滤波器。使用 Geant4 的蒙特卡罗代码计算水模中碳离子束的质量。对模拟结果进行修正，使其与深度剂量分布的测量值一致。除碳离子以外的碎片的生物学响应的计算假设为氦离子。将设计的脊滤波器的测量剂量分布与计算分布进行了比较。该可调节方法的束修改系统已成功应用于群马大学的碳离子治疗。
