Zhou Chao, Choe Regine, Shah Natasha, Durduran Turgut, Yu Guoqiang, Durkin Amanda, Hsiang David, Mehta Rita, Butler John, Cerussi Albert, Tromberg Bruce J, Yodh Arjun G
University of Pennsylvania, Department of Physics & Astronomy, Philadelphia, Pennsylvania 19104, USA.
J Biomed Opt. 2007 Sep-Oct;12(5):051903. doi: 10.1117/1.2798595.
We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHbT/N=69+/-21%), oxyhemoglobin (rctO2HbT/N=73+/-25%), total hemoglobin (rctTHbT/N=72+/-17%), and lipid concentration (rctLipidT/N=116+/-13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N=75+/-7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.
我们将漫射光学光谱法（DOS）和漫射相关光谱法（DCS）相结合，以无创监测一名乳腺癌患者对新辅助化疗的早期血流动力学反应。结果证明了早期治疗监测的潜力。在治疗的第一周（第7天），与治疗前（第0天）相比，DOS显示肿瘤/正常组织的脱氧血红蛋白浓度（rctHHbT/N = 69±21%）、氧合血红蛋白浓度（rctO2HbT/N = 73±25%）、总血红蛋白浓度（rctTHbT/N = 72±17%）和脂质浓度（rctLipidT/N = 116±13%）有显著变化。同样，DCS发现肿瘤/正常组织的血流对比有显著变化（第7天相对于第0天，rBFT/N = 75±7%）。我们的观察结果表明，与单独使用任何一种技术相比，DCS和DOS相结合可增强治疗监测。这种混合方法还能够构建反映组织氧代谢率的指标，这可能为治疗机制提供新的见解。
