Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
Antimicrob Agents Chemother. 2012 Dec;56(12):6425-9. doi: 10.1128/AAC.01494-12. Epub 2012 Oct 1.
ICESp1116, responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, was comprehensively characterized, and its chromosomal integration site was determined. It displayed a unique mosaic organization consisting of a scaffold, related to TnGallo1 from Streptococcus gallolyticus, with two inserted fragments separated by IS1216. One fragment, containing erm(B), displayed high-level identity to a portion of the S. pyogenes plasmid pSM19035; the other, containing a truncated tet(M) gene, displayed high-level identity to the right-hand portion of Clostridium difficile Tn5397.
ICESP1116 负责酿脓链球菌中 erm(B)介导的诱导性红霉素耐药性，其功能已被全面研究，并确定了其染色体整合位点。它表现出一种独特的镶嵌组织形式，由一个支架组成，与来自鹑鸡肠球菌的 TnGallo1 有关，其中有两个插入片段由 IS1216 隔开。一个片段含有 erm(B)，与酿脓链球菌质粒 pSM19035 的一部分具有高度同源性；另一个片段含有截断的 tet(M)基因，与艰难梭菌 Tn5397 的右手部分具有高度同源性。
