在衍射光学天平上进行分子层检测。
Molecular layer detection on a diffractive optical balance.
机构信息
Department of Physics, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
Opt Lett. 2012 Oct 1;37(19):4098-100. doi: 10.1364/OL.37.004098.
Abstract
Diffraction-based molecular detection is achieved by etching optical gratings into thermal oxide on silicon. The gratings perform as a stable common-path diffractive optical balance (DOB) designed to operate near a missing diffraction order. The biosensor is operated in an off-null condition with a phase bias to produce a high-contrast responsivity that is linear in accumulated molecules but with a low background. The DOB linear responsivity is a factor of 20 larger than the reflectometric responsivity of planar thermal oxide.
摘要
基于衍射的分子检测是通过在硅上的热氧化层中刻蚀光学光栅来实现的。这些光栅作为一种稳定的公共路径衍射光学平衡（DOB），设计用于在缺失衍射级附近工作。生物传感器在非零相偏条件下工作，产生高对比度的响应，该响应与累积分子呈线性关系，但背景较低。DOB 的线性响应比平面热氧化层的反射响应大 20 倍。
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