Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Org Lett. 2012 Oct 19;14(20):5342-5. doi: 10.1021/ol302525m. Epub 2012 Oct 3.
A Cu-catalyzed aminoacetoxylation of N-alkenylamidines has been achieved using PhI(OAc)(2) as an oxygen source for synthesis of 4-acetoxymethyl-4,5-dihydroimidazoles, which could be further converted into 2,3-diaminopropanol derivatives using AlH(3) as a reductant.
实现了一种使用 PhI(OAc)(2) 作为氧源的 Cu 催化 N-烯基脒的氨乙酰氧基化反应，用于合成 4-乙酰甲氧基-4,5-二氢咪唑，后者可以进一步用 AlH(3) 作为还原剂转化为 2,3-二氨基丙醇衍生物。
