Teles Juliana Souto, Fukuda Ellen Yukie, Feder David
Undergraduate Course of Medicine, Faculdade de Medicina do ABC - FMABC, Santo Andre (SP), Brazil.
Einstein (Sao Paulo). 2012 Jan-Mar;10(1):110-5. doi: 10.1590/s1679-45082012000100024.
Oral anticoagulants are among the drugs with the greatest number of drug interactions. The concomitant use of several medications is a common practice in patients with cardiovascular problems, who often also present with depression; therefore, the probability of an interaction occurring between warfarin and the antidepressants is high, and may result in increased or decreased anticoagulant activity. Since the possible interactions between these two classes of drugs have been poorly explored in literature, with a risk to the patients who use them, we reviewed the pharmacology of warfarin and its possible interactions with antidepressants. Of the antidepressants analyzed, those that showed relevant effects on the interaction with warfarin were, in decreasing order: paroxetine, venlafaxine, fluoxetine, and duloxetine.
口服抗凝剂是药物相互作用最多的药物之一。在患有心血管疾病的患者中，同时使用多种药物是常见的做法，这些患者常常还伴有抑郁症；因此，华法林与抗抑郁药之间发生相互作用的可能性很高，可能会导致抗凝活性增加或降低。由于这两类药物之间可能的相互作用在文献中研究较少，对使用它们的患者存在风险，我们综述了华法林的药理学及其与抗抑郁药可能的相互作用。在所分析的抗抑郁药中，对与华法林相互作用显示出相关影响的药物，按影响程度从高到低依次为：帕罗西汀、文拉法辛、氟西汀和度洛西汀。
