Department of Dermatology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Int J Dermatol. 2013 May;52(5):614-9. doi: 10.1111/j.1365-4632.2012.05673.x. Epub 2012 Oct 9.
Various methods of photodynamic therapy (PDT) for acne have been introduced. However, comparative studies among them are still needed. We performed this study to compare the effect of methyl aminolevulinate (MAL) PDT for acne between red light and intense pulsed light (IPL). Twenty patients were enrolled in this eight-week, prospective, split-face study. We applied MAL cream over the whole face with a three-hour incubation time. Then patients were irradiated with 22 J/cm(2) of red light on one-half of the face and 8-10 J/cm(2) of IPL on the other half during each treatment session. We performed three treatment sessions at two-week intervals and followed-up patients until four weeks after the last session. Inflammatory and non-inflammatory acne lesions were reduced significantly on both sides. The red light side showed a better response than the IPL side after the first treatment. Serious adverse effects after treatment were not observed. MAL-PDT with red light and IPL are both an effective and safe modality in acne treatment. Red light showed a faster response time than IPL. After multiple sessions, both light sources demonstrated satisfactory results. We suggest that reducing the total dose of red light is desirable when performing MAL-PDT in Asian patients with acne compared with Caucasians.
已经引入了各种光动力疗法 (PDT) 治疗痤疮的方法。然而，仍需要对它们进行比较研究。我们进行这项研究是为了比较氨甲环酸 (MAL) PDT 治疗痤疮时红光与强脉冲光 (IPL) 的效果。二十名患者参与了这项为期八周的前瞻性、分面研究。我们在整个面部涂抹 MAL 乳膏，并进行三小时的孵育。然后，在每次治疗中，我们在面部的一半照射 22 J/cm² 的红光，在另一半照射 8-10 J/cm² 的 IPL。我们每两周进行三次治疗，在最后一次治疗后四周内对患者进行随访。在两侧，炎性和非炎性痤疮病变均显著减少。在第一次治疗后，红光侧的反应比 IPL 侧好。治疗后未观察到严重不良反应。红光和 IPL 的 MAL-PDT 都是治疗痤疮的有效且安全的方法。红光比 IPL 显示出更快的反应时间。经过多次治疗，两种光源均取得了令人满意的效果。我们建议，与白人患者相比，在亚洲痤疮患者中进行 MAL-PDT 时，减少红光的总剂量是可取的。
