脑卒中后对脑抗原免疫反应的激活。
Activation of immune responses to brain antigens after stroke.
机构信息
University of Washington School of Medicine, Harborview Medical Center, Seattle, WA, USA.
出版信息
J Neurochem. 2012 Nov;123 Suppl 2(0 2):148-55. doi: 10.1111/j.1471-4159.2012.07953.x.
Abstract
Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological explanation for this immune dysfunction is that it serves to prevent autoimmune responses to brain antigens. We believe that the systemic immune response in patients who develop infection, however, thwarts this seemingly protective response and predisposes to central nervous system autoimmunity. These autoimmune responses may mediate, at least in part, the worse outcome associated with post-stroke infection.
摘要
感染在中风后很常见，并且与更差的结果独立相关。中风后感染的易感性部分与交感神经介导的外周免疫反应抑制有关。这种免疫功能障碍的目的论解释是，它有助于防止针对脑抗原的自身免疫反应。我们认为，发生感染的患者的全身免疫反应破坏了这种看似保护性的反应，使中枢神经系统自身免疫易于发生。这些自身免疫反应可能至少部分介导了与中风后感染相关的更差结果。
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