Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Fitoterapia. 2012 Dec;83(8):1598-603. doi: 10.1016/j.fitote.2012.09.008. Epub 2012 Oct 7.
Three pairs of monoterpene glycosides (1-6), of which compounds 1, 3, and 4 as new compounds, together with one new monoterpene (7) were obtained from the ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. On this basis, the spectral characteristics of three pairs of monoterpene glycosides were also discussed. The inhibitory effects of isolated compounds on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compounds 4-7.
从牡丹（Paeonia suffruticosa Andrews）的乙醇提取物中分离得到三对对映-单萜糖苷（1-6），其中化合物 1、3 和 4 为新化合物，此外还得到了一个新的单萜（7）。根据化学方法和光谱数据确定了它们的结构。在此基础上，还讨论了三对对映-单萜糖苷的光谱特征。评价了分离得到的化合物对脂多糖激活的巨噬细胞中一氧化氮（NO）产生的抑制作用，化合物 4-7 能显著抑制 NO 的产生。
