Ding Liqin, Zuo Qingfei, Li Dandan, Feng Xinchi, Gao Xiumei, Zhao Feng, Qiu Feng
a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
b School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
Nat Prod Res. 2017 Feb;31(3):253-260. doi: 10.1080/14786419.2016.1230114. Epub 2016 Sep 19.
Thirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inhibitory effects of isolated compounds (1-12) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compound 7.
从牡丹皮的70%乙醇提取物中获得了13种苯甲酰基苯类化合物。通过化学方法和光谱数据确定了它们的结构。其中，化合物1被鉴定为新化合物，化合物5和13首次从芍药属植物中获得。评估了分离得到的化合物（1-12）对脂多糖激活的巨噬细胞中一氧化氮（NO）产生的抑制作用，化合物7显著抑制了NO的产生。
