Haddock Luis J, Flynn Harry W, Dubovy Sander R, Khurana Rahul N, Egbert Peter R
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami Miller School of Medicine, Miami, FL.
Clin Ophthalmol. 2012;6:1573-7. doi: 10.2147/OPTH.S35386. Epub 2012 Sep 25.
A clinicopathologic correlation between two patients with acute-onset Aspergillus endophthalmitis undergoing enucleation is reported. These two patients presented with pain, redness, and decreased vision following uncomplicated cataract surgery. In both patients, vitreous aspiration and intravitreal injections were the initial treatment followed later by pars plana vitrectomy for clinical worsening. Despite repeated surgical and medical interventions, the clinical course of both patients was prolonged, unsuccessful, and resulted in enucleation for a blind painful eye. Histologic examination of the enucleated specimens showed that, in spite of prolonged local and systemic therapy, there was persistent diffuse infiltration of the anterior chamber and ciliary body by a filamentous mold.
报告了两例急性发作的曲霉性眼内炎患者在接受眼球摘除术时的临床病理相关性。这两名患者在白内障手术未出现并发症后出现疼痛、眼红和视力下降。两名患者均首先进行了玻璃体抽吸和玻璃体内注射，随后因病情恶化进行了玻璃体切除术。尽管进行了反复的手术和药物干预，但两名患者的病程均延长且治疗失败，最终因患眼失明疼痛而接受了眼球摘除术。对摘除标本的组织学检查显示，尽管进行了长期的局部和全身治疗，但前房和睫状体仍持续存在丝状霉菌的弥漫性浸润。
