Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., , Rockville, MD 20892, USA.
BMC Cancer. 2012 Oct 11;12:468. doi: 10.1186/1471-2407-12-468.
Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.
To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.
Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).
These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.
先前的研究表明，炎症相关基因中的遗传变异与胆石症和胆道癌有关。
为了跟进这些发现，我们在中国上海的一项基于人群的病例对照研究中，在 456 名胆道癌新发病例（262 例胆囊、141 例肝外胆管、53 例 Vater 壶腹）、982 名胆石症患者和 860 名健康对照者中，检查了与炎症相关的 5 个基因（IL8、NFKBIL、RNASEL、TNF 和 VEGFA）中的 35 个单核苷酸多态性（SNP）。
与胆石症相关的 VEGFA 基因中的 SNP、与胆囊和 Vater 壶腹癌相关的 IL8 基因中的 SNP 以及与 Vater 壶腹癌相关的 RNASEL 基因中的 SNP 存在提示性关联（错误发现率≤0.2）。
这些发现为炎症在胆石症和胆道癌风险中的作用提供了额外的支持，但仍需要进一步验证。
