Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan.
School of Public Health, College of Public Health, Taipei Medical University, Taipei City 11031, Taiwan.
Medicina (Kaunas). 2023 Jul 9;59(7):1278. doi: 10.3390/medicina59071278.
: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both YDM and late-onset type 2 diabetes mellitus (ODM). : There were 36 patients with YDM (23.6 ± 4.8 years) and 36 patients with ODM (54.3 ± 10.1 years) enrolled. Visfatin, RBP4, and MetS components were measured. The relationships between visfatin, RBP4 and MetS components were assessed in YDM and ODM. : The visfatin, but not the RPB4 level, was significantly higher in YDM than in ODM. After adjusting for age and body mass index, visfatin was not related to any MetS components except that there was a negative correlation with fasting plasma glucose (FPG). As for RPB4, triglyceride was found to be positively and FPG negatively related to RBP4 in YDM. However, in ODM, the only positive relationship that existed was between RBP4 and diastolic blood pressure. In conclusion, both visfatin and RBP4 had certain roles in diabetes and MetS although their relationships were different in YDM and ODM. Further studies are needed to explore their physiological and pathological effects in glucose metabolism.
青少年 2 型糖尿病的患病率在近几十年来迅速增加。然而，脂肪因子在青少年起病 2 型糖尿病（YDM）发病机制中的作用尚不清楚。在本文中，我们探讨了脂肪因子（内脏脂肪素和视黄醇结合蛋白 4（RBP4））与 YDM 和晚发 2 型糖尿病（ODM）代谢综合征（MetS）成分之间的关系。
共纳入 36 例 YDM 患者（23.6±4.8 岁）和 36 例 ODM 患者（54.3±10.1 岁）。检测内脏脂肪素、RBP4 和 MetS 成分。评估了 YDM 和 ODM 中内脏脂肪素、RBP4 与 MetS 成分之间的关系。
YDM 患者的内脏脂肪素水平明显高于 ODM 患者，而 RBP4 水平无显著差异。在校正年龄和体重指数后，内脏脂肪素与除空腹血糖（FPG）外的任何 MetS 成分均无相关性。至于 RBP4，在 YDM 中，三酰甘油与 RBP4 呈正相关，FPG 与 RBP4 呈负相关。然而，在 ODM 中，RBP4 仅与舒张压呈正相关。
总之，内脏脂肪素和 RBP4 在糖尿病和 MetS 中均有一定作用，但它们在 YDM 和 ODM 中的关系不同。需要进一步研究以探讨它们在葡萄糖代谢中的生理和病理作用。
