Neyal Munife, Yimenicioglu Fatih, Aydeniz Ali, Taskin Abdullah, Saglam Sadullah, Cekmen Mustafa, Neyal Abdurrahman, Gursoy Savas, Erel Ozcan, Balat Ayse
Gaziantep University Medical School, Neurology Department, Gaziantep, Turkey.
Clin Neurol Neurosurg. 2013 Jun;115(6):736-40. doi: 10.1016/j.clineuro.2012.08.028. Epub 2012 Oct 12.
Tension-type headache (TTH) and fibromyalgia syndrome (FM) are worldwide seen chronic pain syndromes of unknown etiology. Despite the growing body of data on pathophysiology and generation mechanisms of pain; our knowledge on pain mechanisms in both FM and TTH is yet to be limited.
We investigated the plasma nitrite levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in 35 TTH, 33 FM patients and 31 healthy controls.
The mean plasma nitrite levels and TAS levels were significantly low and OSI was found to be significantly high in TTH and FM groups compared to the control group (p=0.001, p=0.001, p=0.001 and p=0.001, respectively). The mean serum TOS levels were also significantly higher in FM group according to the control group (p=0.034), but there was not a significant difference between TTH and control groups (p=0.066).
These results indicated that; FM and TTH patients revealed higher oxidative stress index and lower total nitrite levels than healthy controls. We conclude that oxidative stress may have a role in the pathophysiological mechanisms of TTH and FM, although, whether it is the cause or the consequence, is not clear.
紧张型头痛（TTH）和纤维肌痛综合征（FM）是全球范围内病因不明的慢性疼痛综合征。尽管关于疼痛的病理生理学和产生机制的数据不断增加，但我们对FM和TTH疼痛机制的了解仍然有限。
我们调查了35例TTH患者、33例FM患者和31名健康对照者的血浆亚硝酸盐水平、总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）。
与对照组相比，TTH组和FM组的平均血浆亚硝酸盐水平和TAS水平显著降低，OSI显著升高（分别为p = 0.001、p = 0.001、p = 0.001和p = 0.001）。FM组的平均血清TOS水平也显著高于对照组（p = 0.034），但TTH组与对照组之间无显著差异（p = 0.066）。
这些结果表明，FM和TTH患者的氧化应激指数高于健康对照组，总亚硝酸盐水平低于健康对照组。我们得出结论，氧化应激可能在TTH和FM的病理生理机制中起作用，尽管其是原因还是结果尚不清楚。
