Division of Pediatric Allergy and Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Indoor Air. 2013 Aug;23(4):268-74. doi: 10.1111/ina.12009. Epub 2012 Nov 23.
Home mouse allergen exposure is associated with asthma morbidity, but little is known about the shape of the dose-response relationship or the relevance of location of exposure within the home. Asthma outcome and allergen exposure data were collected every 3 months for 1 year in 150 urban children with asthma. Participants were stratified by mouse sensitization, and relationships between continuous measures of mouse allergen exposure and outcomes of interest were analyzed. Every tenfold increase in the bed mouse allergen level was associated with an 87% increase in the odds of any asthma-related health care use among mouse-sensitized [Odds Ratio (95% CI): 1.87 (1.21-2.88)], but not non-mouse-sensitized participants. Similar relationships were observed for emergency department visit and unscheduled doctor visit among mouse-sensitized participants. Kitchen floor and bedroom air mouse allergen concentrations were also associated with greater odds of asthma-related healthcare utilization; however, the magnitude of the association was less than that observed for bed mouse allergen concentrations. In this population of urban children with asthma, there is a linear dose-response relationship between mouse allergen concentrations and asthma morbidity among mouse-sensitized asthmatics. Bed and bedroom air mouse allergen exposure compartments may have a greater impact on asthma morbidity than other compartments.
家庭老鼠过敏原暴露与哮喘发病率有关，但对于剂量-反应关系的形状以及家庭内暴露位置的相关性知之甚少。在 150 名患有哮喘的城市儿童中，每 3 个月收集一次哮喘结果和过敏原暴露数据，为期 1 年。参与者按鼠致敏情况分层，分析连续测量的鼠过敏原暴露与相关结果之间的关系。在致敏的参与者中，床尘鼠过敏原水平每增加十倍，与任何与哮喘相关的医疗保健使用的几率增加 87%有关（优势比（95%置信区间）：1.87（1.21-2.88）），而非非致敏的参与者。在致敏的参与者中，也观察到了急诊就诊和非计划就诊的类似关系。厨房地板和卧室空气的鼠过敏原浓度也与更大的与哮喘相关的医疗保健使用几率有关；然而，这种关联的程度小于对床尘鼠过敏原浓度的观察结果。在这个患有哮喘的城市儿童人群中，致敏哮喘患者中，鼠过敏原浓度与哮喘发病率之间存在线性剂量-反应关系。床和卧室空气的鼠过敏原暴露室可能比其他室对哮喘发病率的影响更大。
