通过 Rh(III)催化吡啶的氧化环化合成喹啉。
Synthesis of quinolines via Rh(III)-catalyzed oxidative annulation of pyridines.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
出版信息
J Org Chem. 2011 Sep 16;76(18):7583-9. doi: 10.1021/jo201266u. Epub 2011 Aug 22.
PMID:21819061
Abstract
Selective synthesis of quinolines has been achieved via oxidative annulation of functionalized pyridines with two alkyne molecules under Rh(III)-catalyzed cascade C-H activation of pyridines using Cu(OAc)(2) as an oxidant. The selectivity of this reaction is oxidant-dependent, particularly on the anion of the oxidant.
摘要
通过 Rh(III)催化的吡啶 C-H 活化，使用 Cu(OAc)(2)作为氧化剂，实现了功能化吡啶与两个炔烃分子的氧化环化选择性合成喹啉。该反应的选择性与氧化剂有关，特别是与氧化剂的阴离子有关。
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