Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
EMBO Rep. 2012 Nov 6;13(11):971-83. doi: 10.1038/embor.2012.145. Epub 2012 Oct 16.
Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding RNAs contribute to the regulation of mammalian development.
专门的细胞类型从干细胞和祖细胞的分化是在几个层次上紧密调控的，包括在发育过程中和在体组织稳态过程中。许多长非编码 RNA 已被认为是细胞身份特化的额外调控层；这些非编码物种可以通过转录、翻译或信使 RNA 稳定性水平的不同机制，在各种生物学背景下调节基因表达程序。在这里，我们总结了长非编码 RNA 参与哺乳动物细胞分化调控的发现。我们重点讨论了几个有代表性的分化系统，并讨论了特定的长非编码 RNA 如何有助于哺乳动物发育的调控。
