Kkeveetil Chandini Valiyakizha, Thomas Grace, Chander Sam Johnson Udaya
KG Hospital and Postgraduate Research Institute, Coimbatore, India.
Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Coimbatore, India.
Tzu Chi Med J. 2016 Oct-Dec;28(4):143-150. doi: 10.1016/j.tcmj.2016.08.001. Epub 2016 Nov 1.
To assess the effect of micronutrients on health outcomes in patients with heart failure.
Only randomized controlled trials testing the effectiveness of different micronutrients either singly or combined versus placebo in heart failure patients were included. We conducted a search in different databases such as Medline from PubMed, Embase and Scopus from Elsevier, and Google Scholar. The keywords used in the search were "Heart Failure" and its cognates, "Micronutrient," "Minerals," and names of individual micronutrients.
Out of 3288 titles and abstracts reviewed, only 11 trials comprising 529 individuals were found to be appropriate to be included in the final review. It was found that micronutrients, either single or combined, improved the health outcomes of heart failure patients by improving exercise tolerance, functional capacity, left ventricular function, flow-dependent dilation, and inflammatory milieu, thereby improving the quality of life of health failure patients. Certain micronutrients also normalized endothelial dysfunction.
Overall, this systematic review found sufficient evidence to support a large-scale trial on micronutrient supplementation in patients with heart failure.
评估微量营养素对心力衰竭患者健康结局的影响。
仅纳入测试不同微量营养素单独或联合使用与安慰剂相比对心力衰竭患者有效性的随机对照试验。我们在不同数据库进行了检索，如来自PubMed的Medline、来自爱思唯尔的Embase和Scopus，以及谷歌学术。检索中使用的关键词为“心力衰竭”及其同源词、“微量营养素”、“矿物质”以及个别微量营养素的名称。
在审查的3288篇标题和摘要中，仅发现11项试验（涉及529名个体）适合纳入最终审查。结果发现，单独或联合使用的微量营养素通过改善运动耐量、功能能力、左心室功能、血流依赖性扩张和炎症环境，从而改善心力衰竭患者的健康结局，进而提高心力衰竭患者的生活质量。某些微量营养素还可使内皮功能障碍恢复正常。
总体而言，本系统评价发现有充分证据支持针对心力衰竭患者进行微量营养素补充的大规模试验。
