a Department of Cardiology, Discipline of Preventive Cardiology , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.
b Department of Internal Medicine, Discipline of Medical Semiology II , "Victor Babes" University of Medicine and Pharmacy , Timisoara , Romania.
Crit Rev Food Sci Nutr. 2019;59(6):965-981. doi: 10.1080/10408398.2018.1540398. Epub 2018 Dec 3.
Multiple micronutrient supplementation has been suggested to have a role on health outcomes in patients with heart failure (HF), but the evidence is inconclusive.
To elucidate the role of multiple micronutrient supplementation in heart failure we performed a comprehensive review of the literature.
The search in databases included PUBMED (until June 2018) to detect randomized controlled trials (RCTs) and meta-analyzes that investigated the impact of micronutrient supplementation in HF.
With more than 2357 titles and abstracts reviewed, we included only the studies suitable for the final review. Whether alone or in combination, micronutrients have been found to improve the health outcomes of patients with HF by improving symptoms, work capacity and left ventricular ejection fraction (LVEF), thus increasing the quality of life in these patients.
Future studies are needed to document the effects of multiple micronutrient associations in order to include them in nutritional guidelines to increase survival and to improve quality of life in patients with heart failure.
多种微量营养素补充剂被认为对心力衰竭（HF）患者的健康结果有一定作用，但证据尚无定论。
为了阐明多种微量营养素补充在心力衰竭中的作用，我们对文献进行了全面综述。
数据库中的搜索包括 PUBMED（截至 2018 年 6 月），以检测调查微量营养素补充对 HF 影响的随机对照试验（RCT）和荟萃分析。
在审查了超过 2357 个标题和摘要后，我们只纳入了适合最终综述的研究。无论是单独使用还是联合使用，微量营养素都被发现可以通过改善症状、工作能力和左心室射血分数（LVEF）来改善心力衰竭患者的健康结果，从而提高这些患者的生活质量。
需要进一步的研究来记录多种微量营养素联合使用的效果，以便将其纳入营养指南中，以提高心力衰竭患者的生存率和生活质量。
