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FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

作者信息

Iwamoto T, Tsujii E, Ezaki M, Fujie A, Hashimoto S, Okuhara M, Kohsaka M, Imanaka H, Kawabata K, Inamoto Y

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 1990 Jan;43(1):1-7. doi: 10.7164/antibiotics.43.1.

DOI:10.7164/antibiotics.43.1
PMID:2307620
Abstract

FR109615, a new antibiotic active against Candida, was isolated from Streptomyces setonii No. 7562. Based on the spectroscopic data, the structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid (1). The compound showed the excellent in vivo efficacy in a generalized infection test of mice.

摘要

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