Konishi M, Nishio M, Saitoh K, Miyaki T, Oki T, Kawaguchi H
Bristol-Myers Research Institute, Ltd., Tokyo Research Center.
J Antibiot (Tokyo). 1989 Dec;42(12):1749-55. doi: 10.7164/antibiotics.42.1749.
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
