一种新型抗真菌抗生素，FR-900848。I. 生产、分离、理化性质及生物学特性。
A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.
作者信息
Yoshida M, Ezaki M, Hashimoto M, Yamashita M, Shigematsu N, Okuhara M, Kohsaka M, Horikoshi K
机构信息
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
出版信息
J Antibiot (Tokyo). 1990 Jul;43(7):748-54. doi: 10.7164/antibiotics.43.748.
Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5'-amino-5'-deoxy-5,6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings.
热烈链霉菌产生了一种新的抗生素FR - 900848，它对丝状真菌具有高比活性。通过溶剂萃取和柱色谱法纯化后，该化合物呈现为无色晶体。其结构为C32H43N3O6，由5'-氨基-5'-脱氧-5,6-二氢尿苷与一种具有前所未有的四个连续和一个孤立环丙烷环的不饱和脂肪酸组成。
Zotero 插件