抗脂多糖（LPS）抗体的保护效力与LPS诱导的肿瘤坏死因子α及白细胞介素6抑制之间的关联。O侧链特异性抗体与核心LPS抗体的比较。
Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies.
作者信息
Baumgartner J D, Heumann D, Gerain J, Weinbreck P, Grau G E, Glauser M P
机构信息
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
出版信息
J Exp Med. 1990 Mar 1;171(3):889-96. doi: 10.1084/jem.171.3.889.
Abstract
Two-core LPS antibodies, the rabbit J5 polyclonal antiserum and the human anti-lipid A IgM mAb HA-1A, did not improve the survival of mice challenged with E. coli O111 or P. aeruginosa 3, or with the LPS extracted from them, and did not decrease the incidence of Shwartzman reactions in rabbits challenged with O111 LPS. In contrast, O side chain-specific rabbit antisera were protective in these models. The protection afforded by O side chain-specific antisera against endotoxin lethality was associated with decreased LPS-induced serum TNF and IL-6 levels, whereas core LPS antibodies had no effect on TNF or IL-6 levels. The absence of reduction of LPS-induced cytokines levels by core LPS antibodies suggests that these antibodies are not able to prevent the interactions between LPS and target cells.
摘要
两种核心脂多糖抗体，即兔J5多克隆抗血清和人抗脂质A IgM单克隆抗体HA-1A，不能提高经大肠杆菌O111或铜绿假单胞菌3攻击的小鼠的存活率，也不能提高经从它们中提取的脂多糖攻击的小鼠的存活率，并且不能降低经O111脂多糖攻击的兔施瓦茨曼反应的发生率。相比之下，O侧链特异性兔抗血清在这些模型中具有保护作用。O侧链特异性抗血清对内毒素致死性的保护作用与脂多糖诱导的血清TNF和IL-6水平降低有关，而核心脂多糖抗体对TNF或IL-6水平没有影响。核心脂多糖抗体不能降低脂多糖诱导的细胞因子水平，这表明这些抗体无法阻止脂多糖与靶细胞之间的相互作用。
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