线粒体在淋巴瘤中的作用。
A mitochondrial power play in lymphoma.
机构信息
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA.
出版信息
Cancer Cell. 2012 Oct 16;22(4):423-4. doi: 10.1016/j.ccr.2012.09.023.
Abstract
Deregulated energetics is a hallmark of malignancy, but metabolic heterogeneity among individual tumors is unknown. A study by Caro et al. in this issue of Cancer Cell demonstrates that a subset of lymphomas is defined by reliance on mitochondrial energy generation and is selectively killed when this pathway is impaired.
摘要
能量代谢失调是恶性肿瘤的一个标志，但个体肿瘤之间的代谢异质性尚不清楚。Caro 等人在本期《癌细胞》杂志上的一项研究表明，一部分淋巴瘤依赖于线粒体能量生成，当这条通路受到损伤时，该亚群会被选择性杀死。
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