重编程因子Oct4、Sox2和Klf4在诱导多能干细胞生成过程中重置体细胞表观基因组中的作用。
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.
作者信息
Schmidt Ryan, Plath Kathrin
出版信息
Genome Biol. 2012 Oct 22;13(10):251. doi: 10.1186/gb-2012-13-10-251.
Abstract
Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.
摘要
通过特定因子将体细胞重编程为诱导多能干细胞（iPS细胞）是一种在体外进行的人为逆向发育形式。最近的研究已开始阐明这些因子重置表观基因组的分子机制。
Zotero 插件