Barbujani G, Sokal R R
Dipartimento di Biologia, Universita di Padova, Italy.
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1816-9. doi: 10.1073/pnas.87.5.1816.
A newly elaborated method, "Wombling," for detecting regions of abrupt change in biological variables was applied to 63 human allele frequencies in Europe. Of the 33 gene-frequency boundaries discovered in this way, 31 are coincident with linguistic boundaries marking contiguous regions of different language families, languages, or dialects. The remaining two boundaries (through Iceland and Greece) separate descendants of different ethnic or geographical provenance but lack modern linguistic correlates. These findings support a model of genetic differentiation in Europe in which the genetic structure of the population is determined mainly by gene flow and admixture, rather than by adaptation to varying environmental conditions. Of the 33 boundaries, 27 reflect diverse population origins at often distant locations. Language affiliation of European populations plays a major role in maintaining and probably causing genetic differences.
一种新设计的用于检测生物变量突变区域的方法——“沃姆布林法”，被应用于欧洲的63个人类等位基因频率。通过这种方式发现的33个基因频率边界中，有31个与语言边界重合，这些语言边界标记了不同语系、语言或方言的相邻区域。其余两个边界（穿过冰岛和希腊）将不同种族或地理来源的后代分隔开来，但缺乏现代语言上的关联。这些发现支持了欧洲基因分化的一种模型，即人群的遗传结构主要由基因流动和混合决定，而非由对不同环境条件的适应决定。在这33个边界中，有27个反映了通常位于遥远地点的不同人群起源。欧洲人群的语言归属在维持并可能导致遗传差异方面起着主要作用。
