Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J Nutr. 2012 Dec;142(12):2161-6. doi: 10.3945/jn.112.165498. Epub 2012 Oct 24.
Adherence to a Mediterranean-style diet is associated with a lower risk for mortality, cognitive decline, and dementia. Whether adherence to a Mediterranean-style diet protects against age-related frailty is unclear. Therefore, our objective was to examine the association between a Mediterranean-style diet with the risk of frailty in community-dwelling older persons. We conducted longitudinal analyses using data from 690 community-living persons (≥65 y) who were randomly selected from a population registry in Tuscany, Italy. Participants of the Invecchiare in Chianti study of aging completed the baseline examination in 1998-2000 and were re-examined at least once over 6 y. Adherence to a Mediterranean-style diet (scored 0-9, modeled categorically as ≤3, 4-5, and ≥6) was computed from the European Prospective Investigation into Cancer and nutrition FFQ previously validated in this cohort. Frailty was defined as having at least 2 of the following criteria: poor muscle strength, feeling of exhaustion, low walking speed, and low physical activity. After a 6-y follow-up, higher adherence (score ≥6) to a Mediterranean-style diet was associated with lower odds of developing frailty [OR = 0.30 (95% CI: 0.14, 0.66)] compared with those with lower adherence (score ≤3). A higher adherence to a Mediterranean-style diet at baseline was also associated with a lower risk of low physical activity (OR = 0.62; 95% CI: 0.40, 0.96) and low walking speed [OR = 0.48 (95% CI: 0.27, 0.86)] but not with feelings of exhaustion and poor muscle strength. In community-dwelling older adults, higher adherence to a Mediterranean-style diet was inversely associated with the development of frailty.
遵循地中海式饮食与降低死亡率、认知能力下降和痴呆风险相关。然而，地中海式饮食是否能预防与年龄相关的虚弱仍不清楚。因此，我们的目的是研究地中海式饮食与社区居住的老年人虚弱风险之间的关系。我们使用来自意大利托斯卡纳地区人口登记处随机选择的 690 名（≥65 岁）社区居住者的数据进行了纵向分析。衰老的因奇安蒂研究的参与者在 1998-2000 年完成了基线检查，并在至少 6 年内至少接受了一次复查。地中海式饮食的依从性（评分 0-9，分类为≤3、4-5 和≥6）是根据以前在该队列中验证过的欧洲前瞻性癌症与营养 FFQ 计算得出的。虚弱被定义为至少有以下两个标准：肌肉力量差、疲惫感、行走速度慢和体力活动少。经过 6 年的随访，与低依从性（评分≤3）相比，较高的地中海式饮食依从性（评分≥6）与较低的虚弱发生几率相关[OR=0.30（95%CI：0.14，0.66）]。基线时较高的地中海式饮食依从性也与较低的低体力活动风险相关（OR=0.62；95%CI：0.40，0.96）和较低的行走速度[OR=0.48（95%CI：0.27，0.86）]相关，但与疲惫感和肌肉力量差无关。在社区居住的老年人中，较高的地中海式饮食依从性与虚弱的发展呈负相关。
