Rocca Maria A, Valsasina Paola, Fazio Raffaella, Previtali Stefano C, Messina Roberta, Falini Andrea, Comi Giancarlo, Filippi Massimo
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Hum Brain Mapp. 2014 Feb;35(2):513-26. doi: 10.1002/hbm.22198. Epub 2012 Oct 25.
To investigate, using resting state (RS) functional connectivity (FC), the selectivity of involvement of the sensorimotor network in patients with acquired (A) and with hereditary (H) peripheral neuropathies (PN) and the correlations of RS FC abnormalities with clinical impairment and structural brain damage. Temporal associations among RS networks were also explored.
RS fMRI scans were acquired from 13 APN, 12 HPN, and 18 age- and sex-matched healthy controls. Independent component analysis and functional network connectivity were used to investigate RS FC within and among RS networks with potential functional relevance.
Compared to controls, patients had a decreased FC of the right precentral gyrus and an increased RS FC of the precuneus within the sensorimotor network. Both decreased and increased RS FC also involved the visual and auditory networks, which additionally had an increased coherence of function with the sensorimotor network (more pronounced in HPN). RS FC modifications in patients extended to several cognitive networks and were correlated with disease duration. In APN, they were also correlated with the severity of clinical impairment and corpus callosum atrophy.
In PN, RS FC modifications extend beyond the sensorimotor network and involve other sensory and cognitive networks. The correlations between RS FC patterns and disease duration in patients as well as with clinical impairment in patients with APN suggest that modifications of FC might reflect an adaptive mechanism, which takes time to occur and helps to limit the clinical consequences of peripheral damage.
利用静息态（RS）功能连接（FC），研究后天性（A）和遗传性（H）周围神经病（PN）患者感觉运动网络受累的选择性，以及RS FC异常与临床损伤和脑结构损伤的相关性。还探讨了RS网络之间的时间关联。
对13例后天性PN患者、12例遗传性PN患者和18例年龄及性别匹配的健康对照者进行RS fMRI扫描。采用独立成分分析和功能网络连接分析，研究具有潜在功能相关性的RS网络内部及之间的RS FC。
与对照组相比，患者感觉运动网络内右侧中央前回的FC降低，楔前叶的RS FC增加。RS FC降低和增加均涉及视觉和听觉网络，且这些网络与感觉运动网络的功能一致性增加（在遗传性PN中更明显）。患者的RS FC改变扩展到多个认知网络，且与疾病持续时间相关。在后天性PN中，还与临床损伤严重程度和胼胝体萎缩相关。
在PN中，RS FC改变超出感觉运动网络，还涉及其他感觉和认知网络。患者RS FC模式与疾病持续时间以及后天性PN患者临床损伤之间的相关性表明，FC改变可能反映了一种适应性机制，这种机制需要时间来发生，并有助于限制周围损伤的临床后果。
