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大流行性猪流感病毒(H1N1):一种具有威胁性的演变。

Pandemic swine influenza virus (H1N1): A threatening evolution.

机构信息

Department of Respiratory Virology, V. P. Chest Institute, University of Delhi, Delhi, India.

出版信息

Indian J Microbiol. 2009 Dec;49(4):365-9. doi: 10.1007/s12088-009-0064-3. Epub 2010 Jan 7.

Abstract

"Survival of the fittest" is an old axiom laid down by the great evolutionist Charles Darwin and microorganisms seem to have exploited this statement to a great extent. The ability of viruses to adapt themselves to the changing environment has made it possible to inhabit itself in this vast world for the past millions of years. Experts are well versed with the fact that influenza viruses have the capability to trade genetic components from one to the other within animal and human population. In mid April 2009, the Centers for Disease Control and Prevention and the World Health Organization had recognized a dramatic increase in number of influenza cases. These current 2009 infections were found to be caused by a new strain of influenza type A H1N1 virus which is a re-assortment of several strains of influenza viruses commonly infecting human, avian, and swine population. This evolution is quite dependent on swine population which acts as a main reservoir for the reassortment event in virus. With the current rate of progress and the efforts of heath authorities worldwide, we have still not lost the race against fighting this virus. This article gives an insight to the probable source of origin and the evolutionary progress it has gone through that makes it a potential threat in the future, the current scenario and the possible measures that may be explored to further strengthen the war against pandemic.

摘要

“适者生存”是伟大的进化论者查尔斯·达尔文提出的一个古老公理,微生物似乎在很大程度上利用了这一说法。病毒适应不断变化的环境的能力使得它们在过去的数百万年里能够在这个广阔的世界中生存下来。专家们深知,流感病毒有能力在动物和人类群体中相互交换遗传成分。2009 年 4 月中旬,疾病控制和预防中心以及世界卫生组织已经认识到流感病例数量的急剧增加。这些当前的 2009 年感染是由一种新型甲型 H1N1 流感病毒引起的,这种病毒是几种常见感染人类、禽类和猪群的流感病毒的重组。这种进化在很大程度上依赖于猪群,猪群是病毒重组事件的主要宿主。随着目前的进展速度和全球卫生当局的努力,我们还没有输掉与这种病毒的斗争。本文深入探讨了这种病毒可能的起源和进化过程,以及它在未来可能成为潜在威胁的原因、当前的情况以及可能探索的措施,以进一步加强对抗大流行的战争。

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