Khanna Madhu, Kumar Binod, Gupta Ankit, Kumar Prashant
Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, 110007 India.
Indian J Virol. 2012 Jun;23(1):12-7. doi: 10.1007/s13337-012-0066-3. Epub 2012 Mar 25.
The recent pandemic by novel influenza A (H1N1) 2009 (pH1N1) virus is an emerging viral infection, being of significant international concern and requires intensive research. The virus spread in pandemic proportions, and continues to be in the post-pandemic phase. Since, the pH1N1 is still circulating in the community, monitoring is required during the post-pandemic period. The pH1N1 defied influenza seasonality and rapidly became dominant over the seasonal influenza viruses. This new strain was antigenically different from the seasonal H1N1 influenza strains due to the genetic re-assortment. Surprisingly, this new reassortant virus emerged at the end of influenza season, caused a sudden toll of mild illness and is now co-circulating with the seasonal strains. The recent outbreak of pH1N1 consolidates the fact that a new reassortant virus may have originated in animal reservoirs and got transferred to human who were in close contact with these animals. There is a continued need for multisite surveillance to detect potentially dangerous influenza strains, which may emerge and establish themselves in human population. This review is an attempt to address the lessons learnt from the recent influenza pandemic and the future implications for prevention and control of influenza.
2009年甲型H1N1流感（pH1N1）病毒引发的近期大流行是一种新出现的病毒感染，引起了国际社会的重大关注，需要深入研究。该病毒以大流行的规模传播，目前仍处于大流行后阶段。由于pH1N1仍在社区中传播，因此在大流行后时期需要进行监测。pH1N1突破了流感季节性规律，迅速超过季节性流感病毒成为主导毒株。由于基因重配，这种新毒株在抗原性上与季节性H1N1流感毒株不同。令人惊讶的是，这种新的重配病毒在流感季节末期出现，导致突然出现大量轻症病例，目前正与季节性毒株共同传播。近期pH1N1的爆发强化了这样一个事实，即一种新的重配病毒可能起源于动物宿主，并传播给了与这些动物密切接触的人类。持续需要进行多地点监测，以发现可能出现并在人群中立足的潜在危险流感毒株。本综述旨在探讨从近期流感大流行中吸取的教训以及对流感预防和控制的未来影响。
