Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Galway, Ireland.
Gastroenterol Clin North Am. 2012 Dec;41(4):869-76. doi: 10.1016/j.gtc.2012.08.006.
Probiotics have a long record of safety, which relates primarily to lactobacilli and bifidobacteria. Experience with other forms of probiotic is more limited. There is no such thing as zero risk, particularly in the context of certain forms of host susceptibility. There is poor public understanding of the concept of risk, in general, and risk/benefit analysis, in particular. Uncertainty persists regarding the potential for transfer of antibiotic resistance with probiotics, but the risk seems to be low with currently available probiotic products. As with other forms of therapeutics, the safety of probiotics should be considered on a strain-by-strain basis.
益生菌的安全性记录由来已久，这主要与乳杆菌属和双歧杆菌属有关。其他形式的益生菌的经验则更为有限。在某些宿主易感性的情况下，没有零风险这回事。一般来说，公众对风险概念和风险/收益分析的理解很差。关于益生菌可能具有抗生素耐药性转移的潜力仍然存在不确定性，但目前可用的益生菌产品的风险似乎很低。与其他形式的治疗方法一样，应该逐株考虑益生菌的安全性。
