Department of Pediatrics and Child Health, University of Otago, Wellington, Wellington, New Zealand.
J Pediatr. 2013 Apr;162(4):765-9. doi: 10.1016/j.jpeds.2012.09.019. Epub 2012 Oct 25.
To assess nocturnal sleep duration by actigraphy in children with Prader-Willi syndrome (PWS).
Baseline measurements including height, weight, and body mass index (BMI) were collected on 8 children with PWS (6 boys) with each subject age- and sex-matched to 2 control children. From 7 consecutive nights of actigraphy data, values for total sleep time (TST), sleep efficiency, sleep latency (SL), number of awakenings after sleep onset, and duration of awakenings after sleep onset (WASO) were extracted. Parents also completed a sleep diary and questionnaire during this period.
Subjects with PWS ranged from 4.2 to 15.4 years, and they had a lower height z score and higher BMI z score compared with controls. The PWS group had a shorter SL (P = .0007), longer WASO (P = .009), and higher daytime sleepiness score. TST, sleep efficiency, and number of awakenings after sleep onset were not significantly different between the groups, and subjects with PWS did not wake earlier than controls. There was no correlation between WASO and BMI or between WASO and sleepiness score.
Children with PWS appear to have a shorter SL but more time awake in the night than normal children and have similar TST and morning wake time compared with controls.
通过活动记录仪评估 Prader-Willi 综合征（PWS）儿童的夜间睡眠时间。
对 8 名 PWS 儿童（6 名男孩）进行基线测量，包括身高、体重和体重指数（BMI），每个受试者与 2 名对照儿童按年龄和性别匹配。从 7 个连续的活动记录仪数据中，提取总睡眠时间（TST）、睡眠效率、睡眠潜伏期（SL）、睡眠起始后觉醒次数和睡眠起始后觉醒持续时间（WASO）的值。在此期间，家长还完成了睡眠日记和问卷调查。
PWS 组的受试者年龄在 4.2 至 15.4 岁之间，与对照组相比，他们的身高 z 评分较低，BMI z 评分较高。PWS 组的 SL 较短（P=0.0007），WASO 较长（P=0.009），白天嗜睡评分较高。两组的 TST、睡眠效率和睡眠起始后觉醒次数无显著差异，PWS 组的受试者醒来时间并不早于对照组。WASO 与 BMI 或 WASO 与嗜睡评分之间无相关性。
与正常儿童相比，PWS 儿童的 SL 似乎较短，但夜间醒来的时间更多，与对照组相比，他们的 TST 和早晨醒来时间相似。
